Name | LOC14 |
---|---|
Supplier | Tocris Bioscience |
Catalog | 1077 |
Prices | $129.00, $535.00 |
Sizes | 10 mg, 50 mg |
Function Type | Modulator |
Cas Number | 877963-94-5 |
Chemical Name | 2-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]methyl]-1,2-benzisothiazol-3(2H)-one |
Formula | C16H19N3O2S |
Molecular Weight | 317.41 |
Purity | >98 % |
Description | High affinity protein disulfide isomerase (PDI) modulator (K d = 62 nM). Forces PDI to adopt an oxidized conformation and suppresses its activity. Neuroprotective. |
Supplier Page | Shop |
Torfs H, Shariatmadari R, Guerrero F, Parmentier M, Poels J, Van Poyer W, Swinnen E, De Loof A, Akerman K, Vanden Broeck J. J Neurochem. 2000 May;74(5):2182-9.
Isaac RE, Parkin ET, Keen JN, Nassel DR, Siviter RJ, Shirras AD. Peptides. 2002 Apr;23(4):725-33.