LOE 908 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2690
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 143482-60-4
• Chemical Name: 3,4-Dihydro-6,7-dimethoxy-α-phenyl-N,N-bis[2-(2,3,4-trimethoxyphenyl)ethyl]-1-isoquinolineacetamidehydrochloride
• Formula: C41H48N2O9.HCl
• Molecular Weight: 749.29
• Purity: >98 %
• Description: Broad spectrum cation channel blocker. Inhibits several cation channels including store-operated calcium channels (SOCs), voltage-operated calcium channels (VOCs), non-selective cation channels (NSCCs), AMPA, NMDA, Na + and K + channels. Neuroprotective; reduces cortical infarct size and improves neurological outcome following middle cerebral artery occlusion.

Product References

LOE 908 blocks delayed rectifier type potassium channels in PC12 cells and - LOE 908 blocks delayed rectifier type potassium channels in PC12 cells and

Krause E, Pfeiffer F, Schmid A, Arndts D, Schulz I. Biochem Biophys Res Commun. 1998 Mar 27;244(3):659-64.

Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in - Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in

Tatlisumak T, Carano RA, Takano K, Meiler MR, Li F, Sotak CH, Arndts D, Pschorn U, Fisher M. J Neurol Sci. 2000 Sep 15;178(2):107-13.

The broad-spectrum cation channel blocker pinokalant (LOE 908 MS) reduces brain - The broad-spectrum cation channel blocker pinokalant (LOE 908 MS) reduces brain

Christensen T, Wienrich M, Ensinger HA, Diemer NH. Basic Clin Pharmacol Toxicol. 2005 Apr;96(4):316-24.