Lomeguatrib

• Supplier: Tocris Bioscience
• Catalog: 2545
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 192441-08-0
• Chemical Name: 6-[(4-Bromo-2-thienyl)methoxy]-9H-purin-2-amine
• Formula: C10H8BrN5OS
• Molecular Weight: 326.17
• Purity: >98 %
• Description: Inhibitor of O 6 -methylguanine-DNA methyltransferase (MGMT); (IC 50 = 0.009 μ M in cell-free extracts from HeLa S3 cells); attenuates MGMT activity in vitro and in vivo . Enhances the antitumor activity of temozolomide (Cat. No. 2706) in both human melanoma and MCF-7 xenografts.

Product References

Monosaccharide-linked inhibitors of O(6)-methylguanine-DNA methyltransferase - Monosaccharide-linked inhibitors of O(6)-methylguanine-DNA methyltransferase

Reinhard J, Hull WE, von der Lieth CW, Eichhorn U, Kliem HC, Kaina B, Wiessler M. J Med Chem. 2001 Nov 22;44(24):4050-61.

Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous - Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous

Barvaux VA, Lorigan P, Ranson M, Gillum AM, McElhinney RS, McMurry TB, Margison GP. Mol Cancer Ther. 2004 Oct;3(10):1215-20.

O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour - O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour

Clemons M, Kelly J, Watson AJ, Howell A, McElhinney RS, McMurry TB, Margison GP. Br J Cancer. 2005 Nov 14;93(10):1152-6.