Lonidamine

• Supplier: Tocris Bioscience
• Catalog: 4359
• Prices: $89.00, $375.00
• Sizes: 10 mg, 50 mg
• Cas Number: 50264-69-2
• Chemical Name: 1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylicacid
• Formula: C15H10Cl2N2O2
• Molecular Weight: 321.16
• Purity: >98 %
• Description: Anticancer and antispermatogenic agent in vitro and in vivo . Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl - channels in vitro .

Product References

Effects of Lonidamine (AF 1890) and its analogues on follicle-stimulating - Effects of Lonidamine (AF 1890) and its analogues on follicle-stimulating

Lobl TJ, Bardin CW, Gunsalus GL, Musto NA. Chemotherapy. 1981;27 Suppl 2:61-76.

Effects of Lonidamine on murine and human tumor cells in vitro. A morphological - Effects of Lonidamine on murine and human tumor cells in vitro. A morphological

De Martino C, Battelli T, Paggi MG, Nista A, Marcante ML, D'Atri S, Malorni W, Gallo M, Floridi A. Oncology. 1984;41 Suppl 1:15-29.

Lonidamine: in vitro/in vivo correlations. - Lonidamine: in vitro/in vivo correlations.

Teicher BA. Eur J Cancer. 1994;30A(10):1411-3.

Mechanism of lonidamine inhibition of the CFTR chloride channel. - Mechanism of lonidamine inhibition of the CFTR chloride channel.

Gong X, Burbridge SM, Lewis AC, Wong PY, Linsdell P. Br J Pharmacol. 2002 Nov;137(6):928-36.