Loreclezole hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3087
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 117857-45-1
• Chemical Name: (Z)-1-[2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazolehydrochloride
• Formula: C10H6Cl3N3.HCl
• Molecular Weight: 311
• Purity: >99 %
• Description: Subtype-selective GABA A receptor modulator. Acts as a positive allosteric modulator of β 2 or β 3-subunit containing receptors. Also acts as a negative modulator at a novel regulatory site, enhancing GABA A receptor sensitization. Inhibits homomeric ρ 1 GABA C receptors.

Product References

Loreclezole enhances apparent desensitization of recombinant GABAA receptor - Loreclezole enhances apparent desensitization of recombinant GABAA receptor

Donnelly JL, MacDonald RL. Neuropharmacology. 1996;35(9-10):1233-41.

Loreclezole inhibition of recombinant alpha1beta1gamma2L GABA(A) receptor single - Loreclezole inhibition of recombinant alpha1beta1gamma2L GABA(A) receptor single

Fisher JL, Hinkle DJ, Macdonald RL. Neuropharmacology. 2000 Jan 4;39(2):235-45.

Loreclezole as a simple functional marker for homomeric rho type GABA(C) - Loreclezole as a simple functional marker for homomeric rho type GABA(C)

Thomet U, Baur R, Dodd RH, Sigel E. Eur J Pharmacol. 2000 Nov 17;408(2):R1-2.

Compounds exhibiting selective efficacy for different beta subunits of human - Compounds exhibiting selective efficacy for different beta subunits of human

Smith AJ, Oxley B, Malpas S, Pillai GV, Simpson PB. J Pharmacol Exp Ther. 2004 Nov;311(2):601-9. Epub 2004 Jun 21.