| Name | Lovastatin |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3798 |
| Prices | $89.00, $375.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 75330-75-5 |
| Chemical Name | (2S)-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl-2-methylbutanoate |
| Formula | C24H36O5 |
| Molecular Weight | 404.54 |
| Purity | >98 % |
| Description | Potent, competitive inhibitor of HMG-CoA reductase (K i = 0.6 nM) therefore decreases cholesterol biosynthesis, in vitro and in vivo . Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro . Inactive lactam prodrug of lovastatin hydroxy acid, naturally bioactivated in vivo following oral administration. |
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