LUF 5834

• Supplier: Tocris Bioscience
• Catalog: 5427
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 333962-91-7
• Chemical Name: 2-Amino-4-(4-hydroxyphenyl)-6-[(1H-imidazol-2-ylmethyl)thio]-3,5-pyridinecarbonitrile
• Formula: C17H12N6OS
• Molecular Weight: 348.38
• Purity: >98 %
• Description: Potent A 2A and A 2B adenosine receptor partial agonist ( K i = 2.6 nM and EC 50 = 12 nM respectively). Also exhibits selectivity for A 1 over A 3 (K i values are 2.6 and 538 nM respectively).

Product References

New, non-adenosine, high-potency agonists for the human adenosine A2B receptor - New, non-adenosine, high-potency agonists for the human adenosine A2B receptor

Beukers MW, Chang LC, von Frijtag Drabbe Kunzel JK, Mulder-Krieger T, Spanjersberg RF, Brussee J, IJzerman AP. J Med Chem. 2004 Jul 15;47(15):3707-9.

A novel nonribose agonist, LUF5834, engages residues that are distinct from those - A novel nonribose agonist, LUF5834, engages residues that are distinct from those

Lane JR, Klein Herenbrink C, van Westen GJ, Spoorendonk JA, Hoffmann C, IJzerman AP. Mol Pharmacol. 2012 Mar;81(3):475-87.