LY 215840

• Supplier: Tocris Bioscience
• Catalog: 4141
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 137328-52-0
• Chemical Name: [8β(1S,2R)]-N-(2-Hydroxycyclopentyl)-6-methyl-1-(1-methylethyl)-ergoline-8-carboxamide
• Formula: C24H33N3O2
• Molecular Weight: 395.54
• Purity: >98 %
• Description: 5-HT 2 /5-HT 7 receptor antagonist. Reduces stimulatory effect of serotonin on aldosterone secretion; also reduces 5-HT-induced cAMP formation (pK B = 8.26).

Product References

LY215840, a high-affinity 5-HT7 receptor ligand, blocks serotonin-induced - LY215840, a high-affinity 5-HT7 receptor ligand, blocks serotonin-induced

Cushing DJ, Zgombick JM, Nelson DL, Cohen ML. J Pharmacol Exp Ther. 1996 Jun;277(3):1560-6.

Activation of 5-HT(7) receptor in rat glomerulosa cells is associated with an - Activation of 5-HT(7) receptor in rat glomerulosa cells is associated with an

Lenglet S, Louiset E, Delarue C, Vaudry H, Contesse V. Endocrinology. 2002 May;143(5):1748-60.

Expression of serotonin7 receptor and coupling of ectopic receptors to protein - Expression of serotonin7 receptor and coupling of ectopic receptors to protein

Louiset E, Contesse V, Groussin L, Cartier D, Duparc C, Barrande G, Bertherat J, Vaudry H, Lefebvre H. J Clin Endocrinol Metab. 2006 Nov;91(11):4578-86. Epub 2006 Sep 5.