| Name | LY 2183240 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1523 |
| Prices | $115.00, $245.00 |
| Sizes | 1 mg, 10 mg |
| Function Type | Blocker |
| Cas Number | 874902-19-9 |
| Chemical Name | 5-[(1,1'-Biphenyl]-4-yl)methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamide |
| Formula | C17H17N5O |
| Molecular Weight | 307.35 |
| Purity | >98 % |
| Description | Novel and highly potent blocker of anandamide uptake (IC 50 = 270 pM). Inhibits fatty acid amide hydrolase (FAAH) activity (IC 50 = 12.4 nM). Following i.p. administration in rats, increases brain anandamide concentration and exerts antinociceptive effects in formalin model of pain. |
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Alexander JP, Cravatt BF. J Am Chem Soc. 2006 Aug 2;128(30):9699-704.
Dickason-Chesterfield AK, Kidd SR, Moore SA, Schaus JM, Liu B, Nomikos GG, Felder CC. Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):407-23. Epub 2006 May 31.