LY 233053

• Supplier: Tocris Bioscience
• Catalog: 1286
• Prices: $89.00, $185.00, $755.00
• Sizes: 1 mg, 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 125546-04-5
• Chemical Name: (2R*,4S*)-4-(1H-Tetrazol-5-ylmethyl)-2-piperidinecarboxylicacid
• Formula: C8H13N5O2
• Molecular Weight: 211.22
• Purity: >99 %
• Description: Competitive NMDA receptor antagonist (IC 50 = 7 nM) that displays no affinity for AMPA or kainate receptors at a concentration of 10 μ M. Inhibits NMDA-induced neuronal degeneration and protects from NMDA-induced convulsions in neonatal rats.

Product References

Pharmacological characterization of LY233053: a structurally novel - Pharmacological characterization of LY233053: a structurally novel

Schoepp DD, Ornstein PL, Leander JD, Lodge D, Salhoff CR, Zeman S, Zimmerman DM. J Pharmacol Exp Ther. 1990 Dec;255(3):1301-8.

Efficacy of LY233053, a competitive glutamate antagonist, in experimental central - Efficacy of LY233053, a competitive glutamate antagonist, in experimental central

Madden KP, Clark WM, Kochhar A, Zivin JA. J Neurosurg. 1992 Jan;76(1):106-10.

Delayed therapy of experimental ischemia with competitive N-methyl-D-aspartate - Delayed therapy of experimental ischemia with competitive N-methyl-D-aspartate

Madden KP, Clark WM, Zivin JA. Stroke. 1993 Jul;24(7):1068-71.