| Name | LY 2365109 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1019 |
| Prices | $199.00, $825.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 868265-28-5 |
| Chemical Name | N-[2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycinehydrochloride |
| Formula | C22H27NO5.HCl |
| Molecular Weight | 421.91 |
| Purity | >98 % |
| Description | Potent and selective glycine transporter 1 (GlyT1) inhibitor (IC 50 values are 15.8 and > 30 000 nM at GlyT1 and GlyT2 respectively). Induces a dose-dependent elevation in CSF levels of glycine, and enhances acetylcholine and dopamine release in the striatum and prefrontal cortex respectively. Produces profound locomotor and respiratory impairments at higher doses. |
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