LY 255283

• Supplier: Tocris Bioscience
• Catalog: 4969
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 117690-79-6
• Chemical Name: 1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]ethanone
• Formula: C19H28N4O3
• Molecular Weight: 360.46
• Purity: >98 %
• Description: Selective, competitive antagonist of BLT 2 receptors (IC 50 values are ~ 1 and > 10 μ M at human recombinant BLT 2 and BLT 1 receptors respectively). Inhibits LTB 4 -induced contraction of lung parenchyma (pA 2 = 7.2), and reduces LTB 4 -mediated airway obstruction in guinea pigs following i.v. and oral administration. .

Product References

Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones. - Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones.

Herron DK, Goodson T, Bollinger NG, Swanson-Bean D, Wright IG, Staten GS, Thompson AR, Froelich LL, Jackson WT. J Med Chem. 1992 May 15;35(10):1818-28.

Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist. - Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist.

Silbaugh SA, Stengel PW, Cockerham SL, Roman CR, Saussy DL Jr, Spaethe SM, Goodson T Jr, Herron DK, Fleisch JH. Eur J Pharmacol. 1992 Nov 13;223(1):57-64.

Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, - Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor,

Yokomizo T, Kato K, Hagiya H, Izumi T, Shimizu T. J Biol Chem. 2001 Apr 13;276(15):12454-9. Epub 2001 Jan 18.