LY 303511

• Supplier: Tocris Bioscience
• Catalog: 1130
• Prices: $129.00
• Sizes: 5 mg
• Function Type: Inhibitor
• Cas Number: 154447-38-8
• Chemical Name: 2-(1-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one
• Formula: C19H18N2O2
• Molecular Weight: 306.36
• Purity: >99 %
• Description: Negative control compound with respect to LY 294002 (Cat. No. 1130) PI 3-kinase inhibitory activity. Blocks voltage-gated potassium (K v ) channels (IC 50 = 64.6 μ M) and inhibits IL-1 β -stimulated NF- κ B activation, attenuating MCP-1 expression. Antiproliferative. Also inhibits the BET bromodomain proteins BRD2, BRD3 and BRD4.

Product References

The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) - The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V)

El-Kholy W, Macdonald PE, Lin JH, Wang J, Fox JM, Light PE, Wang Q, Tsushima RG, Wheeler MB. FASEB J. 2003 Apr;17(6):720-2. Epub 2003 Feb 5.

LY294002 inhibits monocyte chemoattractant protein-1 expression through a - LY294002 inhibits monocyte chemoattractant protein-1 expression through a

Choi EK, Park HJ, Ma JS, Lee HC, Kang HC, Kim BG, Kang IC. FEBS Lett. 2004 Feb 13;559(1-3):141-4.

LY303511 (2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via - LY303511 (2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via

Kristof AS, Pacheco-Rodriguez G, Schremmer B, Moss J. J Pharmacol Exp Ther. 2005 Sep;314(3):1134-43. Epub 2005 May 27.