LY 311727

• Supplier: Tocris Bioscience
• Catalog: 3078
• Prices: $199.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 164083-84-5
• Chemical Name: [3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]-phosphonicacid
• Formula: C22H27N2O5P
• Molecular Weight: 430.43
• Purity: >97 %
• Description: Selective secreted phospholipase A 2 (sPLA 2 ) inhibitor (IC 50 values are <1 μ M for group IIA and <50 μ M for group V). Attenuates VEGF-mediated platelet-activating factor (PAF) synthesis in BAEC and HUVEC cells at a concentration of 100 μ M.

Product References

Drug or tool, design or serendipity? - Drug or tool, design or serendipity?

Verlinde CL, Dijkstra BW. Nat Struct Biol. 1995 Jun;2(6):429-32.

VEGF stimulation of endothelial cell PAF synthesis is mediated by group V 14 kDa - VEGF stimulation of endothelial cell PAF synthesis is mediated by group V 14 kDa

Bernatchez PN, Winstead MV, Dennis EA, Sirois MG. Br J Pharmacol. 2001 Sep;134(1):197-205.