LY 315920

Name LY 315920
Supplier Tocris Bioscience
Catalog 3627
Prices $195.00, $805.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 172732-68-2
Chemical Name 2-[[3-(2-Amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]aceticaci
Formula C21H20N2O5
Molecular Weight 380.39
Purity >98 %
Description Selective secreted phospholipase A 2 (sPLA 2 ) inhibitor (IC 50 = 50 - 750 nM for a range of sPLA 2 isoforms). Has no effect on cytosolic PLA 2 or COX-1 and COX-2 activity. Attenuates sPLA 2 -induced thromboxane formation in bronchoalveolar lavage (BAL) cells. Also suppresses sPLA 2 -induced contractions of lung pleural strips ex vivo . Orally available.
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