Name | LY 315920 |
---|---|
Supplier | Tocris Bioscience |
Catalog | 3627 |
Prices | $195.00, $805.00 |
Sizes | 10 mg, 50 mg |
Function Type | Inhibitor |
Cas Number | 172732-68-2 |
Chemical Name | 2-[[3-(2-Amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]aceticaci |
Formula | C21H20N2O5 |
Molecular Weight | 380.39 |
Purity | >98 % |
Description | Selective secreted phospholipase A 2 (sPLA 2 ) inhibitor (IC 50 = 50 - 750 nM for a range of sPLA 2 isoforms). Has no effect on cytosolic PLA 2 or COX-1 and COX-2 activity. Attenuates sPLA 2 -induced thromboxane formation in bronchoalveolar lavage (BAL) cells. Also suppresses sPLA 2 -induced contractions of lung pleural strips ex vivo . Orally available. |
Supplier Page | Shop |
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Oslund RC, Cermak N, Gelb MH. J Med Chem. 2008 Aug 14;51(15):4708-14.