LY 320135

• Supplier: Tocris Bioscience
• Catalog: 5313
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 176977-56-3
• Chemical Name: 4-[[6-Methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]benzonitrile
• Formula: C24H17NO4
• Molecular Weight: 383.4
• Purity: >98 %
• Description: Potent CB 1 receptor antagonist/inverse agonist (K i = 141 nM) with greater than 70-fold selectivity over CB 2 receptors (K i > 10 μ M). Structurally dissimilar from SR 141716A and AM 251. Shows weak binding to both 5-HT 2 (K i = 6.4 μ M) and muscarinic receptors (K i = 2.1 μ M).

Product References

LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the - LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the

Felder CC, Joyce KE, Briley EM, Glass M, Mackie KP, Fahey KJ, Cullinan GJ, Hunden DC, Johnson DW, Chaney MO, Koppel GA, Brownstein M. J Pharmacol Exp Ther. 1998 Jan;284(1):291-7.

Cannabinoid CB1 receptors fail to cause relaxation, but couple via Gi/Go to the - Cannabinoid CB1 receptors fail to cause relaxation, but couple via Gi/Go to the

Holland M, John Challiss RA, Standen NB, Boyle JP. Br J Pharmacol. 1999 Oct;128(3):597-604.

Inverse agonism and neutral antagonism at cannabinoid CB1 receptors. - Inverse agonism and neutral antagonism at cannabinoid CB1 receptors.

Pertwee RG. Life Sci. 2005 Feb 4;76(12):1307-24. Epub 2004 Dec 8.