LY 333531 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2387
• Prices: $165.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 169939-93-9
• Chemical Name: (9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dionehydrochloride
• Formula: C28H28N4O3.HCl
• Molecular Weight: 505.01
• Description: Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKC β I and PKC β II (IC 50 values are 4.7 and 5.9 nM respectively). Selective for PKC β over other PKC isozymes (IC 50 values are 0.052, 0.25, 0.30, 0.36, 0.60 and >100 μ M for PKC η , - δ , - γ , - α , - ε and - ζ respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src).

Product References

(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, - (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H,

Jirousek MR, Gillig JR, Gonzalez CM, Heath WF, McDonald JH 3rd, Neel DA, Rito CJ, Singh U, Stramm LE, Melikian-Badalian A, Baevsky M, Ballas LM, Hall SE, Winneroski LL, Faul MM. J Med Chem. 1996 Jul 5;39(14):2664-71.

Effects of protein kinase C inhibitors on thromboxane production by - Effects of protein kinase C inhibitors on thromboxane production by

Samokhin GP, Jirousek MR, Ways DK, Henriksen RA. Eur J Pharmacol. 1999 Dec 15;386(2-3):297-303.

Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of - Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of

Faul MM, Gillig JR, Jirousek MR, Ballas LM, Schotten T, Kahl A, Mohr M. Bioorg Med Chem Lett. 2003 Jun 2;13(11):1857-9.