LY 334370 hydrochloride

Name LY 334370 hydrochloride
Supplier Tocris Bioscience
Catalog 4738
Prices $199.00, $825.00
Sizes 10 mg, 50 mg
Function Type Agonist
Cas Number 199673-74-0
Chemical Name 4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamidehydrochloride
Formula C21H22FN3O.HCl
Molecular Weight 387.88
Purity >99 %
Description Selective 5-HT 1F receptor agonist (K i values are 1.87, 16.4, > 100 (IC 50 ), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC 50 ) and 3250 nM for 5-HT 1F , 5-HT 1A , 5-HT 4 , 5-HT 1E , 5-HT 1B , 5-HT 1D , 5-HT 2B , 5-HT 2A , 5-HT 7 , 5-HT 6 and 5-HT 2C receptors respectively). Displays antimigraine effects.
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Product References

G-protein activation at 5-HT1A receptors by the 5-ht1F ligand LY334370 in - G-protein activation at 5-HT1A receptors by the 5-ht1F ligand LY334370 in

Dupuis DS, Colpaert FC, Pauwels PJ. Br J Pharmacol. 1998 May;124(2):283-90.

Possible antimigraine mechanisms of action of the 5HT1F receptor agonist - Possible antimigraine mechanisms of action of the 5HT1F receptor agonist

Shepheard S, Edvinsson L, Cumberbatch M, Williamson D, Mason G, Webb J, Boyce S, Hill R, Hargreaves R. Cephalalgia. 1999 Dec;19(10):851-8.