| Name | LY 341495 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3079 |
| Prices | $99.00, $235.00, $965.00 |
| Sizes | 1 mg, 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 201943-63-7 |
| Chemical Name | (2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl)propanoicacid |
| Formula | C20H19NO5 |
| Molecular Weight | 353.37 |
| Purity | >98 % |
| Description | Highly potent and selective group II metabotropic glutamate receptor antagonist (K i /IC 50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGlu 2 , mGlu 3 , mGlu 8 , mGlu 7a , mGlu 1a , mGlu 5a and mGlu 4a receptors respectively). Readily brain penetrant and active in vivo . Disodium salt (Cat. No. 4062) also available. Also available as part of the Group II mGlu Receptor Tocriset™ , Group III mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ . |
| Supplier Page | Shop |
Fitzjohn SM, Bortolotto ZA, Palmer MJ, Doherty AJ, Ornstein PL, Schoepp DD, Kingston AE, Lodge D, Collingridge GL. Neuropharmacology. 1998 Dec;37(12):1445-58.
Kingston AE, Ornstein PL, Wright RA, Johnson BG, Mayne NG, Burnett JP, Belagaje R, Wu S, Schoepp DD. Neuropharmacology. 1998;37(1):1-12.
Ornstein PL, Bleisch TJ, Arnold MB, Kennedy JH, Wright RA, Johnson BG, Tizzano JP, Helton DR, Kallman MJ, Schoepp DD, Herin M. J Med Chem. 1998 Jan 29;41(3):358-78.
Johnson BG, Wright RA, Arnold MB, Wheeler WJ, Ornstein PL, Schoepp DD. Neuropharmacology. 1999 Oct;38(10):1519-29.