LY 344864 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4062
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 1217756-94-9
• Chemical Name: N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamidehydrochloride
• Formula: C21H22N3OF.HCl
• Molecular Weight: 387.88
• Purity: >99 %
• Description: Potent, selective 5-HT 1F receptor agonist (EC 50 = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (K i values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μ M for 5-HT 1F , 5-HT 1A , 5-HT 1B , 5-HT 1D , 5-HT 1E , 5-HT 2B , 5-HT 2C , 5-HT 2A and 5-HT 7 receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration.

Product References

Evidence for serotonin (5-HT)1B, 5-HT1D and 5-HT1F receptor inhibitory effects on - Evidence for serotonin (5-HT)1B, 5-HT1D and 5-HT1F receptor inhibitory effects on

Goadsby PJ, Classey JD. Neuroscience. 2003;122(2):491-8.

5-HT1F receptor agonists in acute migraine treatment: a hypothesis. - 5-HT1F receptor agonists in acute migraine treatment: a hypothesis.

Ramadan NM, Skljarevski V, Phebus LA, Johnson KW. Cephalalgia. 2003 Oct;23(8):776-85.