LY 364947

• Supplier: Tocris Bioscience
• Catalog: 3246
• Prices: $95.00, $199.00
• Sizes: 1 mg, 10 mg
• Function Type: Inhibitor
• Cas Number: 396129-53-6
• Chemical Name: 4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-quinoline
• Formula: C17H12N4
• Molecular Weight: 272.31
• Purity: >99 %
• Description: Selective inhibitor of TGF- β type-I receptor (TGF- β RI, TGFR-I, T β R-I, ALK-5) (IC 50 values are 59, 400 and 1400 nM for TGR- β RI, TGF- β RII and MLK-7K respectively). Inhibits TGF- β -dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC 50 values are 47 and 89 nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay.

Product References

Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole - Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole

Sawyer JS, Anderson BD, Beight DW, Campbell RM, Jones ML, Herron DK, Lampe JW, McCowan JR, McMillen WT, Mort N, Parsons S, Smith EC, Vieth M, Weir LC, Yan L, Zhang F, Yingling JM. J Med Chem. 2003 Sep 11;46(19):3953-6.

Dihydropyrrolopyrazole transforming growth factor-beta type I receptor kinase - Dihydropyrrolopyrazole transforming growth factor-beta type I receptor kinase

Li HY, Wang Y, Heap CR, King CH, Mundla SR, Voss M, Clawson DK, Yan L, Campbell RM, Anderson BD, Wagner JR, Britt K, Lu KX, McMillen WT, Yingling JM. J Med Chem. 2006 Mar 23;49(6):2138-42.

Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA - Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA

Shiou SR, Datta PK, Dhawan P, Law BK, Yingling JM, Dixon DA, Beauchamp RD. J Biol Chem. 2006 Nov 10;281(45):33971-81. Epub 2006 Sep 7.