LY 367385

• Supplier: Tocris Bioscience
• Catalog: 2718
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 198419-91-9
• Chemical Name: (S)-(+)-α-Amino-4-carboxy-2-methylbenzeneaceticacid
• Formula: C10H11NO4
• Molecular Weight: 209.2
• Purity: >99 %
• Description: A selective mGlu 1a receptor antagonist, with an IC 50 value of 8.8 μ M for blockade of quisqualate-induced phosphoinositide hydrolysis vs. > 100 μ M for mGlu 5a , and negligible action on group II and III receptors. Also available as part of the Group I mGlu Receptor Tocriset™ .

Product References

Reduction of sensory and metabotropic glutamate receptor responses in the - Reduction of sensory and metabotropic glutamate receptor responses in the

Salt TE, Turner JP. Neuroscience. 1998 Aug;85(3):655-8.

Neuroprotective activity of the potent and selective mGlu1a metabotropic - Neuroprotective activity of the potent and selective mGlu1a metabotropic

Bruno V, Battaglia G, Kingston A, O'Neill MJ, Catania MV, Di Grezia R, Nicoletti F. Neuropharmacology. 1999 Feb;38(2):199-207.

Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and - Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and

Chapman AG, Yip PK, Yap JS, Quinn LP, Tang E, Harris JR, Meldrum BS. Eur J Pharmacol. 1999 Feb 26;368(1):17-24.