LY 379268

• Supplier: Tocris Bioscience
• Catalog: 1237
• Prices: $349.00, $1,449.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 191471-52-0
• Chemical Name: (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylicacid
• Formula: C7H9NO5
• Molecular Weight: 187.15
• Purity: >99 %
• Description: Highly selective group II mGlu receptor agonist (EC 50 values are 2.69 and 4.48 nM for hmGlu 2 and hmGlu 3 respectively) that displays > 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death in vitro and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active. Caged LY 379268 is also available (Cat. No. 3332).

Product References

LY379268, a potent and selective Group II metabotropic glutamate receptor - LY379268, a potent and selective Group II metabotropic glutamate receptor

Bond A, Ragumoorthy N, Monn JA, Hicks CA, Ward MA, Lodge D, O'Neill MJ. Neurosci Lett. 1999 Oct 8;273(3):191-4.

Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: - Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist:

Bond A, Jones NM, Hicks CA, Whiffin GM, Ward MA, O'Neill MF, Kingston AE, Monn JA, Ornstein PL, Schoepp DD, Lodge D, O'Neill MJ. J Pharmacol Exp Ther. 2000 Sep;294(3):800-9.

(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and - (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and

Collado I, Pedregal C, Mazon A, Espinosa JF, Blanco-Urgoiti J, Schoepp DD, Wright RA, Johnson BG, Kingston AE. J Med Chem. 2002 Aug 15;45(17):3619-29.