LY 393558

• Supplier: Tocris Bioscience
• Catalog: 5064
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 271780-64-4
• Chemical Name: 1-[2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-1(2H)-pyridinyl]ethyl]-3,4-dihydro-3-(1-methylethyl)-6-(methylsulfonyl)-1H-2,1,3-benzothiadiazine-2,2-dioxide
• Formula: C26H31FN4O4S2
• Molecular Weight: 546.68
• Purity: >97 %
• Description: Dual 5-HT 1B/1D receptor antagonist (pK B values are 9.05 and 8.98 respectively) and 5-HT re-uptake inhibitor (pIC 50 = 8.48). Potently antagonizes terminal autoreceptor activity in vitro and increases extracellular 5-HT levels above those evoked by fluoxetine (Cat. No. 0927) in vivo . Also acts as an antagonist at 5-HT 2A and 5-HT 2B receptors (pK i values are 7.29 and 7.35 respectively).

Product References

LY393558, a 5-hydroxytryptamine reuptake inhibitor and 5-HT(1B/1D) receptor - LY393558, a 5-hydroxytryptamine reuptake inhibitor and 5-HT(1B/1D) receptor

Mitchell SN, Greenslade RG, Cooper J. Eur J Pharmacol. 2001 Nov 30;432(1):19-27.

In vitro activity of LY393558, an inhibitor of the 5-hydroxytryptamine - In vitro activity of LY393558, an inhibitor of the 5-hydroxytryptamine

Pullar IA, Boot JR, Carney SL, Cohen ML, Colvin EM, Conway RG, Hardy CH, Lucaites VL, Nelson DL, Schenck KW, Tomlinson R, Wedley S. Eur J Pharmacol. 2001 Nov 30;432(1):9-17.

Functional interactions between 5-hydroxytryptamine receptors and the serotonin - Functional interactions between 5-hydroxytryptamine receptors and the serotonin

Morecroft I, Loughlin L, Nilsen M, Colston J, Dempsie Y, Sheward J, Harmar A, MacLean MR. J Pharmacol Exp Ther. 2005 May;313(2):539-48. Epub 2005 Jan 19.