LY 404187

• Supplier: Tocris Bioscience
• Catalog: 3272
• Prices: $185.00, $755.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 211311-95-4
• Chemical Name: N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide
• Formula: C19H22N2O2S
• Molecular Weight: 342.46
• Purity: >98 %
• Description: Selective AMPA receptor positive allosteric modulator (IC 50 values are 0.15, 0.21, 1.66 and 5.65 μ M for GluA2 i , GluA4 i , GluA3 i and GluA1 i respectively). Potentiates glutamate and AMPA-evoked currents in pre frontal cortex (PFC) pyramidal neurons in vitro . Has no effect on NMDA- or kainate-evoked currents; also has no effect on K + or Na + ion channels. Potentiates PFC glutamatergic synaptic transmission in vitro and in vivo . Induces neurite growth in combination with ( S )-AMPA (Cat. No. 0254) in SH-SY5Y human neuroblastoma cells in vitro . Also reduces MPTP-induced toxicity in mice. Brain penetrant.

Product References

Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid - Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid

Baumbarger PJ, Muhlhauser M, Zhai J, Yang CR, Nisenbaum ES. J Pharmacol Exp Ther. 2001 Jul;298(1):86-102.

LY404187: a novel positive allosteric modulator of AMPA receptors. - LY404187: a novel positive allosteric modulator of AMPA receptors.

Quirk JC, Nisenbaum ES. CNS Drug Rev. 2002 Fall;8(3):255-82.

Neurotrophic actions of the novel AMPA receptor potentiator, LY404187, in rodent - Neurotrophic actions of the novel AMPA receptor potentiator, LY404187, in rodent

O'Neill MJ, Murray TK, Whalley K, Ward MA, Hicks CA, Woodhouse S, Osborne DJ, Skolnick P. Eur J Pharmacol. 2004 Feb 20;486(2):163-74.

Molecular mechanisms of neurite growth with AMPA receptor potentiation. - Molecular mechanisms of neurite growth with AMPA receptor potentiation.

Voss OP, Milne S, Sharkey J, O'Neill MJ, McCulloch J. Neuropharmacology. 2007 Feb;52(2):590-7. Epub 2006 Nov 13.