LY 487379 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2390
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 353229-59-1
• Chemical Name: 2,2,2-Trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(3-pyridinylmethyl)ethanesulfonamidehydrochloride
• Formula: C21H19F3N2O4S.HCl
• Molecular Weight: 488.91
• Purity: >99 %
• Description: Positive allosteric modulator selective for mGlu 2 receptors. Potentiates glutamate-stimulated [ 35 S]GTP γ S binding (EC 50 values are 1.7 and > 10 μ M for mGlu 2 and mGlu 3 receptors respectively). Devoid of any activity at mGlu 5 and mGlu 7 receptors. Promotes cognitive flexibility in a rat model.

Product References

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Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in - Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in

Poisik O, Raju DV, Verreault M, Rodriguez A, Abeniyi OA, Conn PJ, Smith Y. Neuropharmacology. 2005;49 Suppl 1:57-69.

Effects of a positive allosteric modulator of group II metabotropic glutamate - Effects of a positive allosteric modulator of group II metabotropic glutamate

Nikiforuk A, Popik P, Drescher KU, van Gaalen M, Relo AL, Mezler M, Marek G, Schoemaker H, Gross G, Bespalov A. J Pharmacol Exp Ther. 2010 Dec;335(3):665-73.