M 25

• Supplier: Tocris Bioscience
• Catalog: 3629
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Chemical Name: N-[[1-(2-Methoxyphenyl)-1H-indazol-5-yl]methyl]-2-propylpentanamide
• Formula: C23H29N3O2
• Molecular Weight: 379.5
• Purity: >98 %
• Description: Potent Smoothened (Smo) receptor antagonist (IC 50 = 5 nM). Inhibits the Hedgehog signaling pathway. Inhibits Shh induced Gli luciferase reporter activity in Shh-light 2 cells (IC 50 = 5 nM). Antagonizes GSA-10 and SAG -mediated differentiation of the C3H10T1/2 cell line (IC 50 values are 69 and 115 nM, respectively).

Product References

Discovery of N-[(1-aryl-1H-indazol-5-yl)methyl]amides derivatives as smoothened - Discovery of N-[(1-aryl-1H-indazol-5-yl)methyl]amides derivatives as smoothened

Dessole G, Branca D, Ferrigno F, Kinzel O, Muraglia E, Palumbi MC, Rowley M, Serafini S, Steinkuhler C, Jones P. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4191-5.

Discovery, molecular and pharmacological characterization of GSA-10, a novel - Discovery, molecular and pharmacological characterization of GSA-10, a novel

Gorojankina T, Hoch L, Faure H, Roudaut H, Traiffort E, Schoenfelder A, Girard N, Mann A, Manetti F, Solinas A, Petricci E, Taddei M, Ruat M. Mol Pharmacol. 2013 May;83(5):1020-9.