| Name | Maraviroc |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 0935 |
| Prices | $225.00, $925.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 376348-65-1 |
| Chemical Name | 4,4-Difluoro-N-{(1S)-3-[3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl}cyclohexanecarboxamide |
| Formula | C29H41F2N5O |
| Molecular Weight | 513.67 |
| Purity | >99 % |
| Description | Selective CCR5 antagonist; displays potent anti-HIV-1 activity. Prevents the interaction of HIV-1 gp120 and CCR5 (IC 50 = 6.4 nM), inhibiting HIV-1 entry. Exhibits antinociceptive effects in a rat model of neuropathic pain. Also inhibits CCL3 (MIP-1 α ) binding to CCR5. Orally bioavailable. |
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Garcia-Perez J, Rueda P, Staropoli I, Kellenberger E, Alcami J, Arenzana-Seisdedos F, Lagane B. J Biol Chem. 2011 Feb 18;286(7):4978-90.