Margatoxin

• Supplier: Tocris Bioscience
• Catalog: 3756
• Prices: $409.00
• Sizes: 100 µg
• Function Type: Blocker
• Cas Number: 145808-47-5
• Formula: C178H286N52O50S7
• Molecular Weight: 4178.96
• Description: Potent K V 1.3 channel blocker (IC 50 = 36 pM). Displays no effect at calcium-activated channels. Reduces VEGF-induced transmembrane calcium influxes and nitric oxide production in human endothelial cells.

Product References

Purification, characterization, and biosynthesis of margatoxin, a component of - Purification, characterization, and biosynthesis of margatoxin, a component of

Garcia-Calvo M, Leonard RJ, Novick J, Stevens SP, Schmalhofer W, Kaczorowski GJ, Garcia ML. J Biol Chem. 1993 Sep 5;268(25):18866-74.

Margatoxin inhibits VEGF-induced hyperpolarization, proliferation and nitric - Margatoxin inhibits VEGF-induced hyperpolarization, proliferation and nitric

Erdogan A, Schaefer CA, Schaefer M, Luedders DW, Stockhausen F, Abdallah Y, Schaefer C, Most AK, Tillmanns H, Piper HM, Kuhlmann CR. J Vasc Res. 2005 Sep-Oct;42(5):368-76. Epub 2005 Jul 22.