Marimastat

• Supplier: Tocris Bioscience
• Catalog: 3563
• Prices: $129.00, $279.00
• Sizes: 1 mg, 10 mg
• Function Type: Inhibitor
• Cas Number: 154039-60-8
• Chemical Name: (2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide
• Formula: C15H29N3O5
• Molecular Weight: 331.41
• Purity: >99 %
• Description: Broad spectrum inhibitor of MMPs (IC 50 values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). Inhibits peritoneal dissemination of human gastric cancer cells in vivo through inhibition of tumor angiogenesis.

Product References

Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with - Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with

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Reduced angiogenesis in peritoneal dissemination of gastric cancer through - Reduced angiogenesis in peritoneal dissemination of gastric cancer through

Wada N, Otani Y, Kubota T, Kimata M, Minagawa A, Yoshimizu N, Kameyama K, Saikawa Y, Yoshida M, Furukawa T, Fujii M, Kumai K, Okada Y, Kitajima M. Clin Exp Metastasis. 2003;20(5):431-5.

Matrix metalloproteinases participate in osteosarcoma invasion. - Matrix metalloproteinases participate in osteosarcoma invasion.

Bjornland K, Flatmark K, Pettersen S, Aaasen AO, Fodstad O, Maelandsmo GM. J Surg Res. 2005 Aug;127(2):151-6. Epub 2005 Apr 14.