Maritoclax

• Supplier: Tocris Bioscience
• Catalog: 2631
• Prices: $195.00, $805.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1227962-62-0
• Chemical Name: 1,1'-(4,4',5,5'-Tetrachloro[1,3'-bi-1H-pyrrole]-2,2'-diyl)bis[1-2-hydroxyphenyl)methanone
• Formula: C22H12Cl4N2O4
• Molecular Weight: 510.15
• Purity: >97 %
• Description: Mcl-1 inhibitor; disrupts Mcl-1-Bim interaction and induces Mcl-1 proteasomal degradation. Exhibits no effect on Bcl-X L -Bim interaction. Selectively induces apoptosis in Mcl-1-dependent K562 leukemia cells. Sensitizes K562 and Raji cells to ABT-737-induced apoptosis.

Product References

Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that - Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that

Doi K, Li R, Sung SS, Wu H, Liu Y, Manieri W, Krishnegowda G, Awwad A, Dewey A, Liu X, Amin S, Cheng C, Qin Y, Schonbrunn E, Daughdrill G, Loughran TP Jr, Sebti S, Wang HG. J Biol Chem. 2012 Mar 23;287(13):10224-35.

Proteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the - Proteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the

Pandey MK, Gowda K, Doi K, Sharma AK, Wang HG, Amin S. PLoS One. 2013 Nov 4;8(11):e78570.