3-MATIDA

• Supplier: Tocris Bioscience
• Catalog: 1192
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 518357-51-2
• Chemical Name: α-Amino-5-carboxy-3-methyl-2-thiopheneaceticacid
• Formula: C8H9NO4S
• Molecular Weight: 215.23
• Purity: >99 %
• Description: Potent metabotropic glutamate mGlu 1 receptor antagonist (IC 50 = 6.3 μ M at rat mGlu 1a ). Displays ≥ 40-fold selectivity over other receptors: mGlu 5 , mGlu 2 , mGlu 4a (IC 50 > 300 μ M), NMDA and AMPA (IC 50 = 250 μ M). Neuroprotective in cultured murine cortical cells and rat hippocampal slice cultures in vitro . Reduces the volume of ischemia-induced brain infarcts in rats following systemic administration in vivo .

Product References

Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and - Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and

Higashijima T, Burnier J, Ross EM. J Biol Chem. 1990 Aug 25;265(24):14176-86.

G protein-bound conformation of mastoparan-X, a receptor-mimetic peptide. - G protein-bound conformation of mastoparan-X, a receptor-mimetic peptide.

Sukumar M, Higashijima T. J Biol Chem. 1992 Oct 25;267(30):21421-4.

The mechanism of inhibition of the Ca2+-ATPase by mastoparan. Mastoparan - The mechanism of inhibition of the Ca2+-ATPase by mastoparan. Mastoparan

Longland CL, Mezna M, Michelangeli F. J Biol Chem. 1999 May 21;274(21):14799-805.