MaxiPost

• Supplier: Tocris Bioscience
• Catalog: 2196
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 187523-35-9
• Chemical Name: (3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-Indol-2-one
• Formula: C16H10ClF4NO2
• Molecular Weight: 359.7
• Purity: >98 %
• Description: Potassium channel modulator. Acts as a positive modulator at neuronal K v 7 channels and calcium-activated K + channels (BK Ca ) in HEK293 cells. Displays negative modulatory activity at K v 7.1 channels (K i = 3.7 μ M) and GABA A receptors. Displays anxiolytic activity in vivo .

Product References

Catalytic enantioselective fluorination of oxindoles. - Catalytic enantioselective fluorination of oxindoles.

Hamashima Y, Suzuki T, Takano H, Shimura Y, Sodeoka M. J Am Chem Soc. 2005 Jul 27;127(29):10164-5.

Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of - Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of

Korsgaard MP, Hartz BP, Brown WD, Ahring PK, Strobaek D, Mirza NR. J Pharmacol Exp Ther. 2005 Jul;314(1):282-92. Epub 2005 Apr 6.

One man's side effect is another man's therapeutic opportunity: targeting Kv7 - One man's side effect is another man's therapeutic opportunity: targeting Kv7

Jepps TA, Olesen SP, Greenwood IA. Br J Pharmacol. 2013 Jan;168(1):19-27.