MC 1568

• Supplier: Tocris Bioscience
• Catalog: 1901
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 852475-26-4
• Chemical Name: 3-[5-(3-(3-Fluorophenyl)-3-oxopropen-1-yl)-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide
• Formula: C17H15FN2O3
• Molecular Weight: 314.31
• Purity: >96 %
• Description: Selective inhibitor of class IIa histone deacetylases (HDACs). Exhibits tissue-selective inhibition between members of class II deacetylases in vivo ; inhibits HDAC4 and HDAC5 in skeletal muscle and the heart without affecting HDAC3 activity. Arrests myogenesis through the stabilization of myocyte enhancer factor 2D (MEF2D)-HDAC3/4 complex. Displays no inhibition of class I HDAC activity or expression.

Product References

Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and - Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and

Mai A, Massa S, Pezzi R, Simeoni S, Rotili D, Nebbioso A, Scognamiglio A, Altucci L, Loidl P, Brosch G. J Med Chem. 2005 May 5;48(9):3344-53.

Identification of two new synthetic histone deacetylase inhibitors that modulate - Identification of two new synthetic histone deacetylase inhibitors that modulate

Mai A, Jelicic K, Rotili D, Di Noia A, Alfani E, Valente S, Altucci L, Nebbioso A, Massa S, Galanello R, Brosch G, Migliaccio AR, Migliaccio G. Mol Pharmacol. 2007 Nov;72(5):1111-23. Epub 2007 Jul 31.