MC 1742

• Supplier: Tocris Bioscience
• Catalog: 4077
• Prices: $229.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 1776116-74-5
• Chemical Name: 5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide
• Formula: C21H21N3O3S
• Molecular Weight: 395.47
• Purity: >98 %
• Description: Potent class I and IIb HDAC inhibitor (IC 50 values are 7, 20, 40, 100, 110 and 610 nM for HDAC6, HDAC3, HDAC10, HDAC1, HDAC2 and HDAC8, respectively). Suppresses proliferation and induces apoptosis of sarcoma cancer stem cells (CSCs) at concentrations >500 nM. Also induces osteogenesis in sarcoma CSCs at concentrations of 25 - 500 nM .