(±)-McN 5652

• Supplier: Tocris Bioscience
• Catalog: 3438
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 96795-89-0
• Chemical Name: (6R,10bS)-rel-1,2,3,5,6,10b-Hexahydro-6-[4-(methylthio)phenyl]-pyrrolo[2,1-a]isoquinoline
• Formula: C19H21NS
• Molecular Weight: 295.44
• Purity: >98 %
• Description: Potent, high affinity serotonin re-uptake inhibitor; selective in vivo . Displays moderate selectivity over noradrenalin and dopamine re-uptake in vitro (K i values are 0.68, 2.9 and 36.8 nM for inhibition of serotonin, noradrenalin and dopamine uptake respectively in rat brain synaptosomes). Potently potentiates 5-HT-induced effects in vivo following oral administration. Biological activity resides predominantly in the (+)-enantiomer.

Product References

McN-5652: a highly potent inhibitor of serotonin uptake. - McN-5652: a highly potent inhibitor of serotonin uptake.

Shank RP, Vaught JL, Pelley KA, Setler PE, McComsey DF, Maryanoff BE. J Pharmacol Exp Ther. 1988 Dec;247(3):1032-8.

Pyrroloisoquinoline antidepressants. 3. A focus on serotonin. - Pyrroloisoquinoline antidepressants. 3. A focus on serotonin.

Maryanoff BE, Vaught JL, Shank RP, McComsey DF, Costanzo MJ, Nortey SO. J Med Chem. 1990 Oct;33(10):2793-7.

Effects of pyrroloisoquinoline enantiomers ((+)- and (-)-McN-5652-Z) on - Effects of pyrroloisoquinoline enantiomers ((+)- and (-)-McN-5652-Z) on

Smith DF, Jensen PN, Poulsen SH, Mikkelsen EO, Elbaz E, Glaser R. Eur J Pharmacol. 1991 Apr 10;196(1):85-92.