Mdivi 1

• Supplier: Tocris Bioscience
• Catalog: 4205
• Prices: $89.00, $375.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 338967-87-6
• Chemical Name: 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
• Formula: C15H10Cl2N2O2S
• Molecular Weight: 353.22
• Purity: >98 %
• Description: Selective inhibitor of Dnm1 GTPase (IC 50 = 1 - 10 μ M); attenuates Dnm1- and Drp1-mediated mitochondrial division. Inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis.

Product References

A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. - A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis.

Tanaka A, Youle RJ. Mol Cell. 2008 Feb 29;29(4):409-10.

Deciphering the late biosynthetic steps of antimalarial compound FR-900098. - Deciphering the late biosynthetic steps of antimalarial compound FR-900098.

Johannes TW, DeSieno MA, Griffin BM, Thomas PM, Kelleher NL, Metcalf WW, Zhao H. Chem Biol. 2010 Jan 29;17(1):57-64.