MDL 11,939

• Supplier: Tocris Bioscience
• Catalog: 4173
• Prices: $155.00, $645.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 107703-78-6
• Chemical Name: α-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol
• Formula: C20H25NO
• Molecular Weight: 295.42
• Purity: >99 %
• Description: Orally active 5-HT 2A receptor antagonist; displays selectivity for 5-HT 2A receptors over 5-HT 2C receptors (K i values are 0.54, 2.5, 81.6 and ~10,000 nM at rabbit 5-HT 2A , human 5-HT 2A , rabbit 5-HT 2C and human 5-HT 2C receptors respectively).

Product References

Antagonist binding at 5-HT(2A) and 5-HT(2C) receptors in the rabbit: high - Antagonist binding at 5-HT(2A) and 5-HT(2C) receptors in the rabbit: high

Aloyo VJ, Harvey JA. Eur J Pharmacol. 2000 Oct 13;406(2):163-9.

Design, synthesis, and pharmacological characterization of N- and O-substituted - Design, synthesis, and pharmacological characterization of N- and O-substituted

Jensen AA, Plath N, Pedersen MH, Isberg V, Krall J, Wellendorph P, Stensbol TB, Gloriam DE, Krogsgaard-Larsen P, Frolund B. J Med Chem. 2013 Feb 14;56(3):1211-27.