MDL 28170

Name MDL 28170
Supplier Tocris Bioscience
Catalog 1436
Prices $79.00
Sizes 10 mg
Function Type Inhibitor
Cas Number 88191-84-8
Chemical Name N-[N-[(Phenylmethoxy)carbonyl]-L-valyl]-phenylalaninal
Formula C22H26N2O4
Molecular Weight 382.45
Purity >95 %
Description Potent, selective inhibitor of calpain and cathepsin B (K i values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo .
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Product References

Cell-penetrating inhibitors of calpain. - Cell-penetrating inhibitors of calpain.

Mehdi S. Trends Biochem Sci. 1991 Apr;16(4):150-3.

Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor - Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor

Chen ZF, Schottler F, Lee KS. Brain Res. 1997 Sep 19;769(1):188-92.

Postischemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage - Postischemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage

Li PA, Howlett W, He QP, Miyashita H, Siddiqui M, Shuaib A. Neurosci Lett. 1998 May 8;247(1):17-20.