MDL 72527

• Supplier: Tocris Bioscience
• Catalog: 0640
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 93565-01-6
• Chemical Name: N1,N4-Di-2,3-butadienyl-1,4-butanediaminedihydrochloride
• Formula: C12H20N2.2HCl
• Molecular Weight: 265.23
• Description: Polyamine oxidase (POA) inhibitor. Does not inhibit monoamine oxidase or D-Amino acid oxidase. Displays anticancer and neuroprotective activity in vivo .

Product References

N-2,3-Butadienyl-1,4-butanediamine derivatives: potent irreversible inactivators - N-2,3-Butadienyl-1,4-butanediamine derivatives: potent irreversible inactivators

Bey P, Bolkenius FN, Seiler N, Casara P. J Med Chem. 1985 Jan;28(1):1-2.

Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, - Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema,

Dogan A, Rao AM, Hatcher J, Rao VL, Baskaya MK, Dempsey RJ. J Neurochem. 1999 Feb;72(2):765-70.

A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative - A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative

Basu HS, Thompson TA, Church DR, Clower CC, Mehraein-Ghomi F, Amlong CA, Martin CT, Woster PM, Lindstrom MJ, Wilding G. Cancer Res. 2009 Oct 1;69(19):7689-95.