MeBIO

• Supplier: Tocris Bioscience
• Catalog: 5054
• Prices: $155.00
• Sizes: 10 mg
• Cas Number: 667463-95-8
• Chemical Name: (2'Z,3'E)-6-Bromo-1-methylindirubin-3'-oxime
• Formula: C17H12BrN3O2
• Molecular Weight: 370.2
• Purity: >99 %
• Description: Control analog of 6-bromoindirubin-3'-oxime ( BIO , Cat. No. 3194). Displays minimal activity against CDK1/Cyclin B, GSK-3 α / β , and CDK5/p25 (IC 50 values are 92.0, 44-100 and >100 μ M respectively). Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.

Product References

GSK-3-selective inhibitors derived from Tyrian purple indirubins. - GSK-3-selective inhibitors derived from Tyrian purple indirubins.

Meijer L, Skaltsounis AL, Magiatis P, Polychronopoulos P, Knockaert M, Leost M, Ryan XP, Vonica CA, Brivanlou A, Dajani R, Crovace C, Tarricone C, Musacchio A, Roe SM, Pearl L, Greengard P. Chem Biol. 2003 Dec;10(12):1255-66.

Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor - Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor

Knockaert M, Blondel M, Bach S, Leost M, Elbi C, Hager GL, Nagy SR, Han D, Denison M, Ffrench M, Ryan XP, Magiatis P, Polychronopoulos P, Greengard P, Skaltsounis L, Meijer L. Oncogene. 2004 May 27;23(25):4400-12.

Structural basis for the synthesis of indirubins as potent and selective - Structural basis for the synthesis of indirubins as potent and selective

Polychronopoulos P, Magiatis P, Skaltsounis AL, Myrianthopoulos V, Mikros E, Tarricone A, Musacchio A, Roe SM, Pearl L, Leost M, Greengard P, Meijer L. J Med Chem. 2004 Feb 12;47(4):935-46.