2'-MeCCPA

• Supplier: Tocris Bioscience
• Catalog: 2843
• Prices: $255.00
• Sizes: 10 mg
• Function Type: Agonist
• Cas Number: 205171-12-6
• Chemical Name: 2-Chloro-N-cyclopentyl-2'-methyladenosine
• Formula: C16H22ClN5O4
• Molecular Weight: 383.83
• Purity: >98 %
• Description: Potent and highly selective agonist at A 1 adenosine receptors (K i values are 3.3, 9580, 37600 and 1150 nM for human recombinant A 1 , A 2A , A 2B and A 3 receptors respectively). Acts as a full agonist; inhibits forskolin-stimulated adenylyl cyclase activity in rat cortical membranes with an IC 50 value of 13.1 nM.

Product References

2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and - 2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and

Franchetti P, Cappellacci L, Marchetti S, Trincavelli L, Martini C, Mazzoni MR, Lucacchini A, Grifantini M. J Med Chem. 1998 May 7;41(10):1708-15.

Synthesis, biological evaluation, and molecular modeling of ribose-modified - Synthesis, biological evaluation, and molecular modeling of ribose-modified

Cappellacci L, Franchetti P, Pasqualini M, Petrelli R, Vita P, Lavecchia A, Novellino E, Costa B, Martini C, Klotz KN, Grifantini M. J Med Chem. 2005 Mar 10;48(5):1550-62.