Meclizine dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2281
• Prices: $95.00
• Sizes: 50 mg
• Function Type: Activator
• Cas Number: 1104-22-9
• Chemical Name: 1-[(4-Chlorophenyl)phenylmethyl]4-[(3-methylphenyl)methyl]piperazinedihydrochloride
• Formula: C25H27ClN2.2HCl
• Molecular Weight: 463.87
• Purity: >99 %
• Description: Human pregnane X receptor (hPXR) agonist; stronger activator of hPXR than rat PXR. Increases hPXR target gene expression in human hepatocyte primary cultures. Also acts as a histamine H 1 receptor antagonist. Confers neuroprotection in models of polyQ toxicity.

Product References

The major role of peripheral release of histamine and 5-hydroxytryptamine in - The major role of peripheral release of histamine and 5-hydroxytryptamine in

Parada CA, Tambeli CH, Cunha FQ, Ferreira SH. Neuroscience. 2001;102(4):937-44.

Meclizine is neuroprotective in models of Huntington's disease. - Meclizine is neuroprotective in models of Huntington's disease.

Gohil VM, Offner N, Walker JA, Sheth SA, Fossale E, Gusella JF, MacDonald ME, Neri C, Mootha VK. Hum Mol Genet. 2011 Jan 15;20(2):294-300.

Differential effect of meclizine on the activity of human pregnane X receptor and - Differential effect of meclizine on the activity of human pregnane X receptor and

Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TK. J Pharmacol Exp Ther. 2011 Mar;336(3):816-26.