Medetomidine hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4245
• Prices: $129.00, $519.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 86347-15-1
• Chemical Name: 4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazolehydrochloride
• Formula: C13H16N2.HCl
• Molecular Weight: 236.74
• Purity: >99 %
• Description: Potent, highly selective α 2 -adrenoceptor agonist (K i values are 1.08 and 1750 nM for α 2 - and α 1 -adrenoceptors respectively). Displays greater selectivity over α 1 -adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Inhibits twitch response in electrically stimulated mouse vas deferens (pD 2 = 9.0). Active in vivo ; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

Product References

Evidence for medetomidine as a selective and potent agonist at alpha - Evidence for medetomidine as a selective and potent agonist at alpha

Savola JM, Ruskoaho H, Puurunen J, Salonen JS, Karki NT. J Auton Pharmacol. 1986 Dec;6(4):275-84.

Characterization of the selectivity, specificity and potency of medetomidine as - Characterization of the selectivity, specificity and potency of medetomidine as

Virtanen R, Savola JM, Saano V, Nyman L. Eur J Pharmacol. 1988 May 20;150(1-2):9-14.

Medetomidine--a novel alpha 2-adrenoceptor agonist: a review of its - Medetomidine--a novel alpha 2-adrenoceptor agonist: a review of its

Scheinin H, Virtanen R, MacDonald E, Lammintausta R, Scheinin M. Prog Neuropsychopharmacol Biol Psychiatry. 1989;13(5):635-51.