Melperone hydrochloride

Name Melperone hydrochloride
Supplier Tocris Bioscience
Catalog 1193
Prices $89.00, $355.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 1622-79-3
Chemical Name 1-(4-Fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanonehydrochloride
Formula C16H22FNO.HCl
Molecular Weight 299.81
Purity >99 %
Description Atypical neuroleptic; 5-HT 2A /D 2 receptor antagonist (K i values are 120 and 180 nM respectively). Causes an increase in dopamine levels in the medial prefrontal cortex (mPFC) and nucleus accumbens and an increase in ACh in the mPFC. Also binds adrenergic α 1 and α 2 receptors (K i values are 180 and 150 nM respectively).
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Product References

Atypical neuroleptics have low affinity for dopamine D2 receptors or are - Atypical neuroleptics have low affinity for dopamine D2 receptors or are

Seeman P, Corbett R, Van Tol HH. Neuropsychopharmacology. 1997 Feb;16(2):93-110; discussion 111-35.

Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, - Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone,

Ichikawa J, Li Z, Dai J, Meltzer HY. Brain Res. 2002 Nov 29;956(2):349-57.