Melphalan

Name Melphalan
Supplier Tocris Bioscience
Catalog 2495
Prices $85.00
Sizes 50 mg
Cas Number 148-82-3
Chemical Name 4-[Bis(2-Chloroethyl)amino]-L-phenylalanine
Formula C13H18Cl2N2O2
Molecular Weight 305.2
Purity >95 %
Description DNA alkylating agent; induces cytotoxicity through the formation of stable interstrand and intrastrand crosslinks within DNA. Inhibits growth of PC-3 cells (IC 50 values are 0.074 and 0.77 μ g/ml for sequential dosing and single dosing respectively).
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Product References

AN ALKYLATING AGENT FOR MULTIPLE MYELOMA: MELPHALAN. - AN ALKYLATING AGENT FOR MULTIPLE MYELOMA: MELPHALAN.

BLUMBERG BS, ALTER HJ, VISNICH S. JAMA. 1965 Feb 15;191:547-9.

Specificity and kinetics of interstrand and intrastrand bifunctional alkylation - Specificity and kinetics of interstrand and intrastrand bifunctional alkylation

Bauer GB, Povirk LF. Nucleic Acids Res. 1997 Mar 15;25(6):1211-8.

In vitro cytotoxic effect of melphalan and pilot phase II study in - In vitro cytotoxic effect of melphalan and pilot phase II study in

Mougenot P, Bressolle F, Culine S, Solassol I, Poujol S, Pinguet F. Anticancer Res. 2006 May-Jun;26(3B):2197-203.