MEN 10376

• Supplier: Tocris Bioscience
• Catalog: 5531
• Prices: $319.00
• Sizes: 1 mg
• Function Type: Antagonist
• Cas Number: 135306-85-3
• Formula: C57H68N12O10
• Molecular Weight: 1081.24
• Description: Potent and selective NK 2 receptor antagonist (pA 2 = 8.08, rabbit pulmonary artery). Displays > 250-fold selectivity over NK 1 (pA 2 = 5.66, guinea pig ileum) and NK 3 (K i > 10 mM, guinea pig brain). Active in vivo .

Product References

In vivo evidence for tachykininergic transmission using a new NK-2 - In vivo evidence for tachykininergic transmission using a new NK-2

Maggi CA, Giuliani S, Ballati L, Lecci A, Manzini S, Patacchini R, Renzetti AR, Rovero P, Quartara L, Giachetti A. J Pharmacol Exp Ther. 1991 Jun;257(3):1172-8.

Tachykininergic transmission to the circular muscle of the guinea-pig ileum: - Tachykininergic transmission to the circular muscle of the guinea-pig ileum:

Bartho L, Santicioli P, Patacchini R, Maggi CA. Br J Pharmacol. 1992 Apr;105(4):805-10.

Pharmacological characterization of tachykinin-induced intracellular calcium rise - Pharmacological characterization of tachykinin-induced intracellular calcium rise

Subramanian N, Ruesch C, Bertrand C. Biochem Biophys Res Commun. 1994 May 16;200(3):1512-20.