MEN 11270

• Supplier: Tocris Bioscience
• Catalog: 1632
• Prices: $329.00
• Sizes: 500 µg
• Function Type: Antagonist
• Cas Number: 235082-52-7
• Formula: C60H90N20O11S
• Molecular Weight: 1299.56
• Description: Peptide antagonist of the B 2 bradykinin receptor (pK i = 10.3); conformationally constrained cyclized analog of HOE 140 (Cat. No. 3014). Blocks hypotension and bronchoconstriction in vivo . Displays selectivity for B 2 over 29 other receptors and ion channels (pIC 50 < 5.5).

Product References

MEN 11270, A novel selective constrained peptide antagonist with high affinity at - MEN 11270, A novel selective constrained peptide antagonist with high affinity at

Meini S, Quartara L, Rizzi A, Patacchini R, Cucchi P, Giolitti A, Calo G, Regoli D, Criscuoli M, Maggi CA. J Pharmacol Exp Ther. 1999 Jun;289(3):1250-6.

Differences between peptide and nonpeptide B(2) bradykinin receptor antagonists - Differences between peptide and nonpeptide B(2) bradykinin receptor antagonists

Tramontana M, Lecci A, Meini S, Montserrat X, Pascual J, Giuliani S, Quartara L, Maggi CA. J Pharmacol Exp Ther. 2001 Mar;296(3):1051-7.

Interaction of linear and cyclic peptide antagonists at the human B(2) kinin - Interaction of linear and cyclic peptide antagonists at the human B(2) kinin

Cucchi P, Meini S, Quartara L, Giolitti A, Zappitelli S, Rotondaro L, Maggi CA. Peptides. 2002 Aug;23(8):1457-63.