Mepyramine maleate

• Supplier: Tocris Bioscience
• Catalog: 3636
• Prices: $75.00
• Sizes: 100 mg
• Function Type: Agonist
• Cas Number: 59-33-6
• Chemical Name: 2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridinemaleate
• Formula: C17H23N3O.C4H4O4
• Molecular Weight: 401.46
• Description: Selective inverse agonist for the H 1 receptor. Inhibits histamine induced inositol phosphate (InsP) production (log EC 50 = -7.94) and intracellular calcium mobilization. Sequesters G q/11 protein, reducing its availability for other receptors associated with the same signaling pathway.

Product References

Distribution, properties, and functional characteristics of three classes of - Distribution, properties, and functional characteristics of three classes of

Hill SJ. Pharmacol Rev. 1990 Mar;42(1):45-83.

Does the [3H]mepyramine binding site represent the histamine H1 receptor? - Does the [3H]mepyramine binding site represent the histamine H1 receptor?

Liu Q, Horio Y, Fujimoto K, Fukui H. J Pharmacol Exp Ther. 1994 Feb;268(2):959-64.

Mepyramine, a histamine H1 receptor inverse agonist, binds preferentially to a G - Mepyramine, a histamine H1 receptor inverse agonist, binds preferentially to a G

Fitzsimons CP, Monczor F, Fernandez N, Shayo C, Davio C. J Biol Chem. 2004 Aug 13;279(33):34431-9. Epub 2004 Jun 10.