Metastin (human)

• Supplier: Tocris Bioscience
• Catalog: 0568
• Prices: $289.00
• Sizes: 100 µg
• Cas Number: 374683-24-6
• Formula: C258H401N79O78
• Molecular Weight: 5857.49
• Description: Potent endogenous ligand of the kisspeptin receptor (KISS1, GPR54). Binds with high affinity to rat and human KISS1 receptors with K i values of 1.80 and 1.45 nM respectively. Inhibits chemotaxis, invasion and metastasis of human melanomas and breast carcinomas. Stimulates gonadotropin secretion following i.c.v. administration.

Product References

The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of - The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of

Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brezillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, Blanpain C, Schiffmann SN, Vassart G, Parmentier M. J Biol Chem. 2001 Sep 14;276(37):34631-6. Epub 2001 Jul 16.

Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled - Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled

Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M. Nature. 2001 May 31;411(6837):613-7.

A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. - A role for kisspeptins in the regulation of gonadotropin secretion in the mouse.

Gottsch ML, Cunningham MJ, Smith JT, Popa SM, Acohido BV, Crowley WF, Seminara S, Clifton DK, Steiner RA. Endocrinology. 2004 Sep;145(9):4073-7. Epub 2004 Jun 24.